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With regular use, people can develop a tolerance to the active ingredients in party pills. This means they need to take more and more to get the same effect. It is believed that it was a growing tolerance that led some users to begin injecting.
Due to the relatively recent (around 2000) introduction of party pills there is not as much research available as for other drugs. However, it is known that there is a risk of psychological dependence.
There is no known risk of physical dependence on party pills.