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Tolerance does develop with regular use of inhalants.
Dependence on inhalants can be psychological or physical, or both. However, dependence among users is rare considering the total number who have tried inhalants.
With regular use of inhalants psychological dependence can occur. People psychologically dependent on inhalants find that using them becomes far more important than other activities in their life. They crave using and will find it very difficult to stop.
Chronic abuse of inhalants may result in physical dependence. This means the body gets used to functioning with the inhalant present. Abruptly stopping use can cause withdrawal symptoms.